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Rembrandt®
Bleaching Systems
Research Reference Guide

  1. Li, Y., “Effect of Rembrandt Sapphire PAC Light on Bleaching Efficacy of Rembrandt
    2.  Virtuoso Lightning Chairside Bleaching Gel. “ Loma Linda University School Of Dentistry, January 2002.

    The purpose of this study was to evaluate how the Rembrandt Sapphire® Light affected the bleaching efficacy of Rembrandt® Virtuoso® Lightning Gel. The study followed the manufacturer’s bleaching product instructions. The Bioform® Color Ordered Shade Guide was used to assess before-and-after tooth shades. The study concluded that the combination of Rembrandt Virtuoso Lightning Chairside Bleaching Gel with the exposure of Rembrandt Sapphire® Light for either 30 or 60 minutes was highly effective in whitening teeth, the subjects achieved an average of 10 shades whiter. Using the gel with the light for a 60-minute exposure produced 15% and 32% more whitening effect immediately after treatment and after seven days.

  2. THE DENTAL ADVISOR, Clinical Evaluations, 2002.
    3.

    Consultants at THE DENTAL ADVISOR evaluated the Rembrandt Sapphire® Light and awarded it a 5-PLUS (96%) rating. The consultants commented on the small, lightweight, pistol grip handpiece and the time display with the ability to change time settings from the pistol grip handpiece. The Sapphire Light was tested in conjunction with Rembrandt® One-Hour Smile Whitening Program components: Rembrandt® Whitening Crystal, Rembrandt® Lightning Plus Chairside Bleaching Gel, and Paint-On Dental Dam. The consultants also reported that the light produced very good whitening results.

  3. Li, Y., “Comparison of Clinical Efficacy and Safety Between User-Formed and Professionally-Fabricated Trays for Rembrandt Plus Superior Bleaching System.” Loma Linda University School of Dentistry, December, 2001.
    4.

    The study compared the clinical efficacy and safety between user-formed and professionally-fabricated trays for the Rembrandt Plus® Superior Bleaching System. The study determined that the system is effective in whitening teeth regardless of the tray used, and the subjects achieved an average of 10 shades whiter. The study also determined that Rembrandt has no adverse effects on oral or soft tissues when manufacturer’s instructions are followed.

  4. Li, Y., Cartwright, S., Lezama, M., Zhang, W., Feller, R., “Effect of Light Application on an In-Office Bleaching Gel.” Loma Linda University School of Dentistry. JDR 80, Special Issue, January, 2001.
    5.

    The purpose of this study was to compare the bleaching efficacy of Virtuoso® Lightning Gel, with or without a light application, with 20 subjects. The study concluded that light application significantly enhanced the efficacy of the bleaching gel with no adverse clinical effects.

  5. Haywood, Van B., “Current Status of Nightguard Vital Bleaching.” Compendium, June 2000.
    6.

    This is a comprehensive study about nightguard vital bleaching. The study included the six 10% carbamide peroxide products approved by the ADA—Rembrandt bleaching gel was the first bleaching gel to receive ADA acceptance. Study topics included: product composition, laboratory and clinical safety, dentist supervision, limitations of whitening, side effects, fees, and other treatment topics.

  6. Ciancio, S., “A Clinical Evaluation of the Effect of a Bleaching Gel on Patients with Sensitive Teeth.” JDR, Vol. 79, Abs. No. 583 2000:216.
    7.

    The objective of this four-week clinical trial was to determine the safety, whitening effect, and effect on dentinal hypersensitivity of a test bleaching gel on patients with sensitive teeth. The results of the study showed that Rembrandt XTRA-Comfort® does not produce sensitivity in non-sensitive patients and decreases sensitivity in those with sensitive teeth.

  7. Li., Y., et al., “Peroxide Content and Efficacy of Two Office-Use Bleaching Gels,” JDR, Vol. 79, Abs. No. 965 2000:264.
    8.

    The purpose of this study was to compare the peroxide content and bleaching efficacy of an experimental office-use bleaching gel to a commercial office-use bleaching gel. It was concluded that the two gels are effective in whitening teeth; their H2O2 content and bleaching efficacy is comparable; and their bleaching efficacy is dependent upon the treatment time.

  8. Li., Y., et al., “Comparison of Efficacy of an Office Bleaching Gel With and Without Light Treatment Using Extracted Human Anterior Teeth.” Loma Linda University School of Dentistry, 2000.
    9.

    The purpose of this study was to compare the efficacy of an office bleaching gel, with and without the light treatment, using extracted human anterior teeth. It was concluded that the office bleaching gel is effective in reducing tooth shade with or without the light treatment; and the light treatment significantly enhances the bleaching efficacy of the gel.

  9. Thitinanthapan, W., Satamanont, P., Vongsavan, N., “In Vitro Penetration of the Pulp Chamber by Three Brands of Carbamide Peroxide.” Journal of Esthetic Dentistry, Vol. 11, No. 5 1999:259-264.
    10.

    The purpose of this in-vitro study was to measure the quantity of hydrogen peroxide that reaches the pulp chamber from three 10% carbamide peroxide products: Opalescence,™ Sparkle™and Rembrandt®. It was reported that carbamide peroxide penetration to the pulp varies significantly for various commercial bleaching products. — 3.605+ 1.405 mg for Opalescence, 1.282 + 0.762 for Sparkle, and 0.339 + 0.251 for Rembrandt. It was concluded that products with an equal concentration amount of 10% carbamide peroxide might produce a different level of sensitivity.

  10. Munoz, C.A., et. al., “Clinical Evaluation of a Combined In-Office and At-Home Bleaching Agent.” JDR, Vol. 78, Abs. No. 312 1999:144.
    11.

    The efficacy of a combined in-office/at-home bleaching gel, Rembrandt XTRAComfort® with a desensitizing agent, was evaluated in a double-blind clinical trial. It was determined that the addition of a desensitizing agent does not adversely affect the efficacy of the bleaching system and the combined in-office/at-home bleaching method seems to be effective in bleaching teeth. Dramatic results were achieved through two hours a day, seven days of treatment. No sensitivity was observed in the XTRA-Comfort group.

  11. Kugel, G., et al., "Effective Tooth Bleaching in 5 Days: Using a Combined In-Office and At-Home Bleaching System," Compendium, Apr. 1997.
    12.

    This article reports on a clinical study which compared the bleaching efficacy of Quik Start® in-office with Rembrandt Accelerate® combined in-office and at-home procedures. After five days of treatment, the participant using Accelerate demonstrated statistically greater tooth whitening 7.1 shades compared to Quik Start 4.8 shades alone. No negative gingival findings were observed.

  12. The Dental Advisor Plus, Vol. 6, No. 5 Sept.-Oct. 1996.
    13.

    Rembrandt received a 4-STAR rating by the evaluators. Patients found the material easy to use and the tray comfortable to wear. A change of shades was noted in most cases.

  13. The Dental Advisor Plus, Vol. 7, No. 4 July/August, 1997.
    14.

    Rembrandt Accelerate® received a 41/2–STAR rating by the evaluators of The Dental Advisor. It is highly recommended as a combination in-office/at-home bleaching system for faster tooth whitening. A definite shade change was noted by patients after their first 10-15 minute Quik Start® application. Follow-up, at-home treatments with Gel Plus for one hour per day is an excellent complement to the in-office procedure.

  14. Barghi, N., Morgan, J., “A Transitional Treatment.” Dentistry Today, Jun. 1995.
    15.

    Detailed clinical procedures are described in this article. It was determined that both Rembrandt bleaching gel and Quik Start provide safe and effective bleaching. The average shade change was 2.2. No adverse reactions to hard or soft tissue were reported.

  15. Godder, B., et al., “Evaluation of Two At-Home Bleaching Systems.” Journal of Clinical Dentistry, Vol. V 1994: 86-88.
    16.

    This study demonstrated that Rembrandt Gel Plus lightened teeth approximately 3 shades after two weeks of use. Rembrandt caused no gingival sensitivity or irritation.

  16. Li, Y., “Evaluation of Cytotoxicity of Rembrandt Lighten Bleaching Gel Using the Cell Counts and MTT Tetrazolium Assay.” 1993. Unpublished data available on request.
    17.

    Rembrandt Lighten Bleaching Gel showed 10 times less cytotoxicity than other bleaching products Starbrite.

  17. Reinhardt, J.W., et al., “A Clinical Study of Nightguard Vital Bleaching.” Quintessence International, Vol. 24 1993:379-384.
    18.

    It was reported that the use of Rembrandt overnight, and with a three-hour replenishment, produced significant tooth lightening results. The gingival index for this study also indicated an improvement in gingival health for the participants.

  18. Ouellet, D., et al., “Double-Blind Whitening Night-Guard Study Using 10% Carbamide Peroxide.” Journal of Esthetic Dentistry, Vol. 4 1992:80-83.
    19.

    Using a Vita Shade Guide and a colorimeter, Rembrandt showed whitening of three shades over a four-week period. Patients using Rembrandt perceived their teeth to be significantly lighter.

  19. Furnish, G.M., et al. “Success and Longevity of Home Bleaching Using 10% Carbamide Peroxide.” American Association of Dental Research, Abs. 664 (1992).
    20.

    This study showed an average lightening of teeth was four shades whiter on the Vita Shade guide with results stable over one year. There were no long-term detrimental effects of this treatment on soft tissue.

  20. Lavelle, C.L.B., et al., “A Preliminary Clinical Evaluation of Rembrandt Lighten.” University of Manitoba 1992.
    21.

    This study indicates a shade lightening of up to two shades–lasting over one year–when using Rembrandt bleaching system.

  21. Ibsen, R., Ouellet, D., “Clinical Technique for Bleaching with the Rembrandt Whitening System and Quik Start Bleaching Gel.” Journal of Esthetic Dentistry, Vol. 3, No. 5 Sept.-Oct. 1991.
    22.

    A clinical case is described in detail in which Rembrandt Bleaching Gel was used successfully to lighten teeth 1.5 shades in one week.

  22. Scherer, W., Palat, M., Hittelman, E., Putter, H., Cooper, Harmon, “At-Home Bleaching System: Effect on Gingival Tissue.” Journal of Esthetic Dentistry, Vol. 4., No. 3 (1992):86-89.
    23.

    This study evaluated the effects of an at-home vital bleaching system on gingival responses over a six-week period. Vital bleaching was performed as follows: Group1, (Rembrandt Lighten Bleaching Gel) in a prefabricated mouthguard and Group 2, (Rembrandt Lighten Bleaching Gel and Rembrandt Toothpaste) in 1:1 ratio. The results of this study indicated that the Rembrandt Whitening System provides gingival improvement in reducing inflammation and, hence, has a therapeutic effect on gingival tissue.